It is also an intermediate in the production of vanillin from ferulic acid. Received: 31 October 2019 / Revised: 8 November 2019 / Accepted: 9 November 2019 / Published: 13 November 2019, (This article belongs to the Special Issue, Vanillic acid (VA) is a flavoring agent found in edible plants and fruits. It is an oxidized form of vanillin. The conversions of vanillic acid and O-benzylvanillic acid to vanillin were examined by using whole cells and enzyme preparations of Nocardia sp. It contains phenolic acids and derivatives (vanillic acid, syringic acid, p-coumaric acid, o-coumaric acid, gallic acid, caffeic acid, protocatechuic acid, p-hydroxybenzoic acid, ferulic acid, cinnamic acid, 4-(acetoxyethyl)-1,2-dihydroxybenzene, benzoic acid, hydroxy-isocromans), phenolic alcohols (3,4-dihydroxyphenyl-ethanol (3,4-DHPEA), p-hydroxyphenyl-ethanol (p-HPEA) and 3,4-dihdroxyphenyl-ethanol-glucoside), lignins ((+)-1-acetoxypinoresinol, (+)-pinoresinol), flavonols (apigenin, luteolin), and secoiridoids (dialdehydic form of decarboxymethyl elenolic acid linked to 3,4-dihydroxyphenyl-ethanol (3,4-DHPEA-EDA), dialdehydic form of decarboxymethyl elenolic acid linked to p-hydroxyphenyl-ethanol (p-HPEA-EDA), oleuropein aglycone 3,4-dihydroxyphenyl-ethanol linked to elenolic acid (3,4-DHPEA-EA), ligstroside aglycone, oleuropein, p-HPEA-derivative, dialdehydic form of oleuropein aglycone, dialdehydic form of ligstroside aglycone) known to possess multiple biological activities such as antioxidant, anticarcinogenic, anti-inflammatory, antimicrobial, antihypertensive, antidyslipidemic, cardiotonic, laxative, and antiplatelet.39, Massimo D’Archivio, ... Roberta Masella, in Polyphenols in Human Health and Disease, 2014, Nitric oxide (NO) is another key mediator, able to propagate and amplify the inflammatory response. Fathi MAA, Abd El-Hafeez AA, Abdelhamid D, Abbas SH, Montano MM, Abdel-Aziz M. Bioorg Chem.  |  The edible mushroom Lentinus edodes (shiitake) can be cultured in a solid medium, and its extract is commercially available as a nutritional supplement. As expected, the phenolic acids that were not metabolized by L. plantarum cultures were not metabolized by the purified enzyme. It is also an intermediate in the production of vanillin from ferulic acid. Pirogallol was also obtained from gallic acid during the degradation of tannic acid by L. plantarum cell-free extracts (Rodríguez et al., 2008a). Tang JF(1), Lv XH, Wang XL, Sun J, Zhang YB, Yang YS, Gong HB, Zhu HL. 2014 Jan;347(1):1-20. doi: 10.1002/ardp.201300231. All of these compounds are reported for the first time, the chemical structures of these compounds were confirmed by means of (1)H NMR, ESI-MS and elemental analyses. The extract also inhibits proliferation of isolated rat hepatic stellate cells. About Us | displays a wide spectrum of biological activities, e.g. In present study, a series … Buying Leads | Among them, the bioassay results demonstrated that compounds 5c, 5n, 5p, 5o, 6f and 6g exhibited immunosuppressive activities with IC(50) concentration range from 1.25μM to 7.60 μM against the T cells, and the IC(50) of positive control (csa) is 2.12 μM. Finally, the absorbance of the solution in each well at 570 nm is measured using an ApoTox instrument. Specifically, PCA reduces NO production in a dose-dependent manner in LPS-treated RAW 264.7 cells,113 while PCA pretreatment of CCl4 rat results in the reduction of NO levels in plasma.91, Christoph Kellendonk, in Progress in Brain Research, 2009. [citation needed] It is also found in wine and vinegar. Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter, 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. Molecular docking was performed to position compounds 5o and 6f into PI3Kγ binding site in order to indicate the potential target. Author information: (1)State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China. 4: 220. anti-cancer, anti-oxidant, anti-inflammatory, antimicrobial, anti-hyperglycemic and hepatoprotective properties. Few recent studies exhibited robust antibacterial activity of VA against several pathogen microorganisms. You seem to have javascript disabled. Combustible. J Nat Prod. Higher dopamine availability as measured by amphetamine-induced dopamine release should lead to an increased occupancy of D2 receptors in the striatum, which was later found by Anissa Abi-Dargham and colleagues (Abi-Dargham et al., 2000). 1,3,4-oxadiazole/chalcone hybrids: Design, synthesis, and inhibition of leukemia cell growth and EGFR, Src, IL-6 and STAT3 activities. InChI=1S/C8H8O4/c1-12-7-4-5(8(10)11)2-3-6(7)9/h2-4,9H,1H3,(H,10,11). Antibiotics 2019, 8, 220. Vanillic acid is a monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methoxy group at position 3.  |  National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. P, pirogallol; C, catechol. Antipsychotic medication also increases D2 receptor density, but the elevated D2 receptor binding potential has been observed in drug-free and drug-naive patients (Laruelle, 1998). Vanillic acid Biological Activity.

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